DIRECT OBSERVATION OF A TERNARY COMPLEX BETWEEN THE DIMERIC ENZYME HIV-1 PROTEASE AND A SUBSTRATE-BASED INHIBITOR

被引:152
作者
BACA, M [1 ]
KENT, SBH [1 ]
机构
[1] SCRIPPS RES INST, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA
关键词
D O I
10.1021/ja00036a066
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:3992 / 3993
页数:2
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共 20 条
[1]   SOLID-PHASE SYNTHESIS OF HYDROXYETHYLAMINE PEPTIDE-BOND ISOSTERES - SYNTHESIS OF THE POTENT-HIV-1 PROTEASE INHIBITOR JG365 [J].
ALEWOOD, PF ;
BRINKWORTH, RI ;
DANCER, RJ ;
GARNHAM, B ;
JONES, A ;
KENT, SBH .
TETRAHEDRON LETTERS, 1992, 33 (07) :977-980
[2]   ION SPRAY INTERFACE FOR COMBINED LIQUID CHROMATOGRAPHY/ATMOSPHERIC PRESSURE IONIZATION MASS-SPECTROMETRY [J].
BRUINS, AP ;
COVEY, TR ;
HENION, JD .
ANALYTICAL CHEMISTRY, 1987, 59 (22) :2642-2646
[3]   PROBING CONFORMATIONAL-CHANGES IN PROTEINS BY MASS-SPECTROMETRY [J].
CHOWDHURY, SK ;
KATTA, V ;
CHAIT, BT .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (24) :9012-9013
[4]  
Covey T R, 1988, Rapid Commun Mass Spectrom, V2, P249, DOI 10.1002/rcm.1290021111
[5]  
DARKE PL, 1989, J BIOL CHEM, V264, P2307
[6]   HUMAN IMMUNODEFICIENCY VIRUS PROTEASE EXPRESSED IN ESCHERICHIA-COLI EXHIBITS AUTOPROCESSING AND SPECIFIC MATURATION OF THE GAG PRECURSOR [J].
DEBOUCK, C ;
GORNIAK, JG ;
STRICKLER, JE ;
MEEK, TD ;
METCALF, BW ;
ROSENBERG, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (24) :8903-8906
[7]   DESIGN, ACTIVITY, AND 2.8 A CRYSTAL-STRUCTURE OF A C2 SYMMETRICAL INHIBITOR COMPLEXED TO HIV-1 PROTEASE [J].
ERICKSON, J ;
NEIDHART, DJ ;
VANDRIE, J ;
KEMPF, DJ ;
WANG, XC ;
NORBECK, DW ;
PLATTNER, JJ ;
RITTENHOUSE, JW ;
TURON, M ;
WIDEBURG, N ;
KOHLBRENNER, WE ;
SIMMER, R ;
HELFRICH, R ;
PAUL, DA ;
KNIGGE, M .
SCIENCE, 1990, 249 (4968) :527-533
[8]   ELECTROSPRAY IONIZATION FOR MASS-SPECTROMETRY OF LARGE BIOMOLECULES [J].
FENN, JB ;
MANN, M ;
MENG, CK ;
WONG, SF ;
WHITEHOUSE, CM .
SCIENCE, 1989, 246 (4926) :64-71
[9]  
FITZGERALD PMD, 1990, J BIOL CHEM, V265, P14209
[10]   OBSERVATION OF NONCOVALENT ENZYME SUBSTRATE AND ENZYME PRODUCT COMPLEXES BY ION-SPRAY MASS-SPECTROMETRY [J].
GANEM, B ;
LI, YT ;
HENION, JD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (20) :7818-7819