CHEMICAL CLEAVAGE OF PLASMID DNA BY CU(II), NI(II) AND CO(III) DESFERAL COMPLEXES

被引：30

作者：

JOSHI, RR ^{[1
]}

GANESH, KN ^{[1
]}

机构：

[1] NATL CHEM LAB,DIV ORGAN CHEM,BIOORGAN CHEM UNIT,POONA 411008,MAHARASHTRA,INDIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91773-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is demonstrated that the Cu(II), Co(III) and Ni(II) complexes of a siderophore chelating drug desferal cleave DNA, in contrast to the corresponding Fe(II) complex which does not bring about DNA scission. Hydroxy radical scavengers inhibit the cleavage reaction. © 1992.

引用

页码：588 / 592

页数：5

共 29 条

[1] METALS AND DNA - MOLECULAR LEFT-HANDED COMPLEMENTS [J].

BARTON, JK .

SCIENCE, 1986, 233 (4765) :727-734

[2] DESIGN OF A DOUBLE-STRANDED DNA CLEAVING AGENT WITH 2 POLYAMINE METAL-BINDING ARMS - RU(DIP)2MACRON+ [J].

BASILE, LA ;

BARTON, JK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (24) :7548-7550

[3] METAL-ACTIVATED HYDROLYTIC CLEAVAGE OF DNA [J].

BASILE, LA ;

RAPHAEL, AL ;

BARTON, JK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (24) :7550-7551

[4] THE UNUSUAL CONFORMATION ADOPTED BY THE ADENINE TRACTS IN KINETOPLAST DNA [J].

BURKHOFF, AM ;

TULLIUS, TD .

CELL, 1987, 48 (06) :935-943

[5] DNA MODIFICATION - INTRINSIC SELECTIVITY OF NICKEL(II) COMPLEXES [J].

CHEN, XY ;

ROKITA, SE ;

BURROWS, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (15) :5884-5886

[6]

DAVIES SC, 1983, LANCET, V2, P181

[7] DESIGN OF SEQUENCE-SPECIFIC DNA-BINDING MOLECULES [J].

DERVAN, PB .

SCIENCE, 1986, 232 (4749) :464-471

[8]

DOBBIN PS, 1990, CHEM BRIT, V26, P565

[9]

GRAF E, 1984, J BIOL CHEM, V259, P3620

[10] MN(III)-DESFERRIOXAMINE SUPEROXIDE DISMUTASE-MIMIC - ALTERNATIVE MODES OF ACTION [J].

HAHN, SM ;

KRISHNA, CM ;

SAMUNI, A ;

MITCHELL, JB ;

RUSSO, A .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1991, 288 (01) :215-219

← 1 2 3 →