INOSITOL-1,4,5-TRISPHOSPHATE AND NONHYDROLYZABLE GTP ANALOG INDUCED CALCIUM RELEASE FROM INTRACELLULAR STORES OF THE HELIX-POMATIA NEURONS

被引：5

作者：

BELAN, PV

OSIPENKO, ON

TEPIKIN, AV

机构：

[1] A. A. Bogomoletz Institute of Physiology, Academy of Science of Ukranian S.S.R., Bogomoletz str., 4, GSP, Kiev-24

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1990年 / 96卷 / 01期

关键词：

D O I：

10.1016/0742-8413(90)90042-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Cytoplasmic Ca2+ concentration ICaIin and membrane potential of single Helix pomatia neurons was studied by Fura-2 fluorescence measurement and conventional current clamp methods. 2. Intracellular injection of inositol-1,4,5-trisphosphate (IP3) and nonhydrolysable GTP analogue (Gpp/NH/p) led to a rise of ICaIin; in contrast, GTP injection did not cause significant ICaIin changes. 3. We suggest that both IP3 and Gpp/NH/p directly activated Ca release from intracellular stores. © 1990.

引用

页码：45 / 47

页数：3

共 8 条

[1] THE CA SIGNAL FROM FURA-2 LOADED MAST-CELLS DEPENDS STRONGLY ON THE METHOD OF DYE-LOADING [J].

ALMERS, W ;

NEHER, E .

FEBS LETTERS, 1985, 192 (01) :13-18

[2]

BERRIDGE MJ, 1986, J EXP BIOL, V45, P325

[3]

FINK LA, 1988, J NEUROSCI, V8, P2544

[4] GUANINE NUCLEOTIDE-INDUCED AND INOSITOL 1,4,5-TRISPHOSPHATE-INDUCED CALCIUM RELEASE IN RABBIT MAIN PULMONARY-ARTERY [J].

KOBAYASHI, S ;

SOMLYO, AP ;

SOMLYO, AV .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 403 :601-619

[5] THE INTRACELLULAR-DISTRIBUTION OF CALCIUM [J].

MELDOLESI, J ;

VOLPE, P ;

POZZAN, T .

TRENDS IN NEUROSCIENCES, 1988, 11 (10) :449-452

[6] GTP REQUIREMENT FOR INOSITOL-1,4,5-TRISPHOSPHATE-INDUCED CA-2+ RELEASE FROM SARCOPLASMIC-RETICULUM IN SMOOTH-MUSCLE [J].

SAIDA, K ;

VANBREEMEN, C .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 144 (03) :1313-1316

[7]

SAWADA M, 1987, J NEUROSCI, V7, P1470

[8]

TEPIKIN AV, 1987, BIOL MEMBRANY, V4, P882

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