Modulation of Cellular Tropism and Innate Antiviral Response by Viral Glycans

被引：19
作者：
Rogers, Kristin M. [1 ]
Heise, Mark
机构：
[1] Univ N Carolina, Carolina Vaccine Inst, Chapel Hill, NC 27599 USA
来源：
JOURNAL OF INNATE IMMUNITY | 2009年 / 1卷 / 05期
关键词：
Arbovirus; Dendritic cells; Immunity; Glycan; Glycosylation; Lectin; Viral attachment/entry; Virus-host cell interactions; WEST-NILE-VIRUS; C-TYPE LECTIN; PLASMACYTOID DENDRITIC CELLS; DC-SIGN; DENGUE-VIRUS; MANNOSE RECEPTOR; SINDBIS VIRUS; IFN-ALPHA; COMPLEMENT ACTIVATION; IMMUNE-RESPONSES;
D O I：
10.1159/000226422
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Arthropod-borne viruses (arboviruses) area significant cause of human and animal disease worldwide. Multiple interactions between virus and the host innate immune system ultimately determine the pathogenesis and clinical outcome of the infection. Evidence is rapidly emerging that suggests viral glycans play a key role in viral pathogenesis by regulating host cell tropism and interactions with the host innate immune response. Glycan-mediated interactions are especially important for arboviruses which must adapt to variable glycosylation systems and cellular receptors within both vertebrate and invertebrate hosts. This review focuses on emerging evidence which supports a crucial role for viral glycans in mediating host cell tropism and regulating the innate antiviral response. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码：405 / 412
页数：8
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