AGED RATS ARE STILL RESPONSIVE TO THE ANTIDEPRESSANT AND MEMORY-IMPROVING EFFECTS OF OXYTOCIN

被引：34
作者：
ARLETTI, R
BENELLI, A
POGGIOLI, R
LUPPI, P
MENOZZI, B
BERTOLINI, A
机构：
来源：
NEUROPEPTIDES | 1995年 / 29卷 / 03期
关键词：
D O I：
10.1016/0143-4179(95)90021-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 mu g/kg). These results are in agreement with previous data obtained in adult rats and indicate that aging does not compromise the social memory improving and antidepressant-like activities of oxytocin.
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页码：177 / 182
页数：6
相关论文
共 72 条
  • [1] ALBANESE A, 1986, NEUROSCI LETT, V26, pS88
  • [2] ALTMAN HJ, 1986, PSYCHOPHARMACOLOGY, V90, P24
  • [3] [Anonymous], 1994, LONGEVITY SENESCENCE
  • [4] CENTRAL FUNCTIONS OF OXYTOCIN
    ARGIOLAS, A
    GESSA, GL
    [J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1991, 15 (02) : 217 - 231
  • [5] OXYTOCIN ACTS AS AN ANTIDEPRESSANT IN 2 ANIMAL-MODELS OF DEPRESSION
    ARLETTI, R
    BERTOLINI, A
    [J]. LIFE SCIENCES, 1987, 41 (14) : 1725 - 1730
  • [6] SEXUAL-BEHAVIOR OF AGING MALE-RATS IS STIMULATED BY OXYTOCIN
    ARLETTI, R
    BENELLI, A
    BERTOLINI, A
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 179 (03) : 377 - 381
  • [7] OXYTOCIN INHIBITS FOOD AND FLUID INTAKE IN RATS
    ARLETTI, R
    BENELLI, A
    BERTOLINI, A
    [J]. PHYSIOLOGY & BEHAVIOR, 1990, 48 (06) : 825 - 830
  • [8] OXYTOCIN IMPROVES MALE COPULATORY PERFORMANCE IN RATS
    ARLETTI, R
    BAZZANI, C
    CASTELLI, M
    BERTOLINI, A
    [J]. HORMONES AND BEHAVIOR, 1985, 19 (01) : 14 - 20
  • [9] ARLETTI R, 1992, ANN NY ACAD SCI, V652, P180
  • [10] BENELLI A, 1995, IN PRESS NEUROPEPTID
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