CUMULATIVE IRRITANCY IN MAN TO SODIUM LAURYL SULFATE - THE OVERLAP PHENOMENON

被引：21
作者：
PATIL, SM [1 ]
SINGH, P [1 ]
MAIBACH, HI [1 ]
机构：
[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT DERMATOL,SAN FRANCISCO,CA 94143
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 110卷 / 02期
关键词：
SODIUM LAURYL SULFATE; HYDRATION; CUMULATIVE IRRITATION; WATER LOSS;
D O I：
10.1016/0378-5173(94)90152-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Repeated contact of skin with surfactants causes irritation often characterized by dryness, erythema and scaliness. Morphologically healed skin after preexposure can still evoke a stronger reaction to any subsequent exposure of an irritant. Cumulative irritancy using the overlap phenomenon was studied. The effects of repeated and prolonged application of sodium lauryl sulfate (SLS) on human skin in vivo (healthy adult volunteers) were evaluated using non-invasive techniques of TEWL and skin capacitance measurements and visual scoring. The inability of TEWL and skin capacitance to achieve pretreatment values 2 weeks post SLS treatment suggests the possible detrimental effects of SLS on skin lipids. The surfactant effect was cumulative and dehydrating effects on prolonged and repeated application were observed.
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收藏
页码：147 / 154
页数：8
相关论文
共 30 条
[1]   EFFECT OF ORGANIC-SOLVENTS ON IN-VITRO HUMAN SKIN WATER BARRIER FUNCTION [J].
ABRAMS, K ;
HARVELL, JD ;
SHRINER, D ;
WERTZ, P ;
MAIBACH, H ;
MAIBACH, HI ;
REHFELD, SJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1993, 101 (04) :609-613
[2]   SODIUM LAURYL SULFATE FOR IRRITANT PATCH TESTING - A DOSE-RESPONSE STUDY USING BIOENGINEERING METHODS FOR DETERMINATION OF SKIN IRRITATION [J].
AGNER, T ;
SERUP, J .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 95 (05) :543-547
[3]   SKIN REACTIONS TO IRRITANTS ASSESSED BY NON-INVASIVE BIOENGINEERING METHODS [J].
AGNER, T ;
SERUP, J .
CONTACT DERMATITIS, 1989, 20 (05) :352-359
[4]   PERCUTANEOUS-ABSORPTION - TRANSPORT IN THE DERMIS [J].
ALBERY, WJ ;
GUY, RH ;
HADGRAFT, J .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1983, 15 (02) :125-148
[5]   RACIAL-DIFFERENCES IN SODIUM LAURYL SULFATE INDUCED CUTANEOUS IRRITATION - BLACK AND WHITE [J].
BERARDESCA, E ;
MAIBACH, HI .
CONTACT DERMATITIS, 1988, 18 (02) :65-70
[6]   SODIUM LAURYL SULFATE INDUCED CUTANEOUS IRRITATION - COMPARISON OF WHITE AND HISPANIC SUBJECTS [J].
BERARDESCA, E ;
MAIBACH, HI .
CONTACT DERMATITIS, 1988, 19 (02) :136-140
[7]   RANKING OF SURFACTANT SKIN IRRITANCY INVIVO IN MAN USING THE PLASTIC OCCLUSION STRESS TEST (POST) [J].
BERARDESCA, E ;
FIDELI, D ;
GABBA, P ;
CESPA, M ;
RABBIOSI, G ;
MAIBACH, HI .
CONTACT DERMATITIS, 1990, 23 (01) :1-5
[8]  
BILCHMANN CW, 1988, ACTA DERM-VENEREOL, V68, P284
[9]  
BLAKEHASKINS JC, 1986, J SOC COSMET CHEM, V37, P199
[10]   CUTANEOUS SODIUM LAURYL SULFATE IRRITATION POTENTIAL - AGE AND REGIONAL VARIABILITY [J].
CUA, AB ;
WILHELM, KP ;
MAIBACH, HI .
BRITISH JOURNAL OF DERMATOLOGY, 1990, 123 (05) :607-613
123