BIOCHEMICAL MARKERS OF BONE TURNOVER - AN UPDATE

被引：0
作者：
VANDAELE, PLA
BIRKENHAGER, JC
POLS, HAP
机构：
[1] ERASMUS UNIV ROTTERDAM,SCH MED,DEPT INTERNAL MED 3,POB 1738,3000 DR ROTTERDAM,NETHERLANDS
[2] ERASMUS UNIV ROTTERDAM,SCH MED,DEPT EPIDEMIOL & BIOSTAT,3000 DR ROTTERDAM,NETHERLANDS
来源：
NETHERLANDS JOURNAL OF MEDICINE | 1994年 / 44卷 / 02期
关键词：
BIOCHEMICAL MARKERS; OSTEOPOROSIS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Currently, biomarkers are available which have considerably increased the possibility of monitoring changes in bone turnover. Assays for carboxy-terminal procollagen I fragments, osteocalcin and the bone-specific isoenzyme of alkaline phosphatase allow a more precise assessment of the complex osteoblastic functions in health and disease; osteocalcin appears at present to be the most satisfactory one. With respect to bone resorption, the measurement of urinary pyridinoline cross-links seems to be the most reliable assay. It has to be emphasisized, however, that a single biomarker may be of value in some metabolic bone diseases but not in others.
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页码：65 / 72
页数：8
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