DELIVERY CHARACTERISTICS OF ALBUTEROL POWDER AEROSOL BY ROTAHALER

被引：14

作者：

KIM, CS

GARCIA, L

机构：

[1] Human Studies Division, Health Effects Research Laboratory, US Environmental Protection Agency, NC 27711, Research Triangle Park

[2] Baker Cummins Pharmaceuticals, Inc., Miami

来源：

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG | 1993年 / 6卷 / 03期

关键词：

AEROSOL DEPOSITION; DRUG DELIVERY; DRY POWDER;

D O I：

10.1089/jam.1993.6.199

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Delivery characteristics of Rotahaler (200 mug capsule of dry powder) were evaluated for a wide range of inspiratory flow rate. Specific drug doses discharged from Rotahaler and the doses subsequently delivered via an oropharyngeal model were determined by filter sampling and HPLC as a function of inspiratory flow rate. Size distribution of the aerosol was measured at the exit of the oropharyngeal model with a 7-stage cascade impactor. The impactor data were analyzed by both gravimetric and UV spectrophotometric methods. The results show that drug dose (mean +/- SD) discharged from the Rotahaler varied widely from 39+/-32 to 146+/-11 mug in the inspiratory flow range of 30-120 l/min. Of the dose discharged about 24-34% was lost in the oropharyngeal space in the flow range tested. The drug dose delivered via the oropharyngeal model was between 28+/-18 and 110+/-9 mug in the flow range tested: this value represented 15-58% of the unit capsule dose. The delivery dose was consistent only with inspiratory flow rates > 60 l/min. These results and a comparison with a pressurized metered-dose inhaler, Ventolin, are discussed.

引用

页码：199 / 211

页数：13

共 23 条

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