EVIDENCE THAT THE RAD1 AND RAD10 PROTEINS OF SACCHAROMYCES-CEREVISIAE PARTICIPATE AS A COMPLEX IN NUCLEOTIDE EXCISION-REPAIR OF UV-RADIATION DAMAGE

被引：12
|
作者：
SIEDE, W [1 ]
FRIEDBERG, AS [1 ]
FRIEDBERG, EC [1 ]
机构：
[1] UNIV TEXAS, SW MED CTR, DEPT PATHOL, MOLEC PATHOL LAB, DALLAS, TX 75235 USA
来源：
JOURNAL OF BACTERIOLOGY | 1993年 / 175卷 / 19期
关键词：
D O I：
10.1128/JB.175.19.6345-6347.1993
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A newly characterized rad1 missense mutation (rad1-20) in the yeast Saccharomyces cerevisiae maps to a region of the Rad1 polypeptide known to be required for Rad1-Rad10 complex formation. The UV sensitivity of the rad1-20 mutant can be partially and specifically corrected by overexpression of wild-type Rad10 protein. These results suggest that complex formation between the Rad1 and Rad10 proteins is required for nucleotide excision repair.
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页码：6345 / 6347
页数：3
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