THE ROLE OF OXIDIZED LOW-DENSITY LIPOPROTEINS IN THE PATHOGENESIS OF ATHEROSCLEROSIS

被引：0

作者：

PARTHASARATHY, S

STEINBERG, D

WITZTUM, JL

机构：

来源：

ANNUAL REVIEW OF MEDICINE | 1992年 / 43卷

关键词：

LIPID PEROXIDATION; SCAVENGER RECEPTOR; ANTIOXIDANTS; LIPOXYGENASE; FATTY ACID;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hypercholesterolemia is a major risk for atherogenesis. Recent evidence suggests that oxidative modification of the major cholesterol-carrying lipoprotein, low-density lipoprotein (LDL), renders it more atherogenic. Not only does oxidized LDL (Ox-LDL) have enhanced uptake by macrophages, which contributes directly to foam cell formation, it may also adversely affect many other aspects of arterial wall metabolism and thus contribute further to the atherogenic process. Inhibition of the oxidation of LDL may be another approach to inhibiting atherogenesis, additive to or even synergistic with lowering of plasma LDL levels.

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页码：219 / 225

页数：7

相关论文

共 15 条

[1] THE ANTIOXIDANT BUTYLATED HYDROXYTOLUENE PROTECTS AGAINST ATHEROSCLEROSIS [J].

BJORKHEM, I ;

HENRIKSSONFREYSCHUSS, A ;

BREUER, O ;

DICZFALUSY, U ;

BERGLUND, L ;

HENRIKSSON, P .

ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (01) :15-22

[2] THE SCAVENGER CELL PATHWAY FOR LIPOPROTEIN DEGRADATION - SPECIFICITY OF THE BINDING-SITE THAT MEDIATES THE UPTAKE OF NEGATIVELY-CHARGED LDL BY MACROPHAGES [J].

BROWN, MS ;

BASU, SK ;

FALCK, JR ;

HO, YK ;

GOLDSTEIN, JL .

JOURNAL OF SUPRAMOLECULAR STRUCTURE, 1980, 13 (01) :67-81

[3] MINIMALLY MODIFIED LOW-DENSITY-LIPOPROTEIN INDUCES MONOCYTE CHEMOTACTIC PROTEIN-1 IN HUMAN ENDOTHELIAL-CELLS AND SMOOTH-MUSCLE CELLS [J].

CUSHING, SD ;

BERLINER, JA ;

VALENTE, AJ ;

TERRITO, MC ;

NAVAB, M ;

PARHAMI, F ;

GERRITY, R ;

SCHWARTZ, CJ ;

FOGELMAN, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (13) :5134-5138

[4]

GEY KF, 1989, ANN NY ACAD SCI, V570, P268

[5] LOW-DENSITY LIPOPROTEIN PATHWAY AND ITS RELATION TO ATHEROSCLEROSIS [J].

GOLDSTEIN, JL ;

BROWN, MS .

ANNUAL REVIEW OF BIOCHEMISTRY, 1977, 46 :897-930

[6] ENHANCED MACROPHAGE DEGRADATION OF LOW-DENSITY LIPOPROTEIN PREVIOUSLY INCUBATED WITH CULTURED ENDOTHELIAL-CELLS - RECOGNITION BY RECEPTORS FOR ACETYLATED LOW-DENSITY LIPOPROTEINS [J].

HENRIKSEN, T ;

MAHONEY, EM ;

STEINBERG, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10) :6499-6503

[7] TYPE-I MACROPHAGE SCAVENGER RECEPTOR CONTAINS ALPHA-HELICAL AND COLLAGEN-LIKE COILED COILS [J].

KODAMA, T ;

FREEMAN, M ;

ROHRER, L ;

ZABRECKY, J ;

MATSUDAIRA, P ;

KRIEGER, M .

NATURE, 1990, 343 (6258) :531-535

[8] IMPAIRMENT OF ENDOTHELIUM-DEPENDENT ARTERIAL RELAXATION BY LYSOLECITHIN IN MODIFIED LOW-DENSITY LIPOPROTEINS [J].

KUGIYAMA, K ;

KERNS, SA ;

MORRISETT, JD ;

ROBERTS, R ;

HENRY, PD .

NATURE, 1990, 344 (6262) :160-162

[9] ENDOTHELIAL AND SMOOTH-MUSCLE CELLS ALTER LOW-DENSITY LIPOPROTEIN INVITRO BY FREE-RADICAL OXIDATION [J].

MOREL, DW ;

DICORLETO, PE ;

CHISOLM, GM .

ARTERIOSCLEROSIS, 1984, 4 (04) :357-364

[10] INDUCTION OF ENDOTHELIAL-CELL EXPRESSION OF GRANULOCYTE AND MACROPHAGE COLONY-STIMULATING FACTORS BY MODIFIED LOW-DENSITY LIPOPROTEINS [J].

RAJAVASHISTH, TB ;

ANDALIBI, A ;

TERRITO, MC ;

BERLINER, JA ;

NAVAB, M ;

FOGELMAN, AM ;

LUSIS, AJ .

NATURE, 1990, 344 (6263) :254-257