Non-cystic fibrosis bronchiectasis in children and adults. Causes and disease progression

被引：0

作者：

Kurzidim, L. ^{[1
]}

Schwarz, C. ^{[2
]}

Schoenfeld, N. ^{[3
]}

Bauer, T. T. ^{[3
]}

Barker, M. ^{[1
]}

机构：

[1] HELIOS Klinikum Emil Behring, Lungenklinik Heckeshorn, Klin Kinder & Jugendmedizin, Walterhofer Str. 11, D-14165 Berlin, Germany

[2] Univ Med Berlin, Klin Padiatrie Schwerpunkt Pneumologie Immunol, Charite Campus Virchow Klinikum, Berlin, Germany

[3] HELIOS Klinikum Emil Behring, Lungenklinik Heckeshorn, Klin Pneumol, Berlin, Germany

来源：

PNEUMOLOGE | 2014年 / 11卷 / 02期

关键词：

Bronchiectasis; Cystic fibrosis; Non-CF bronchiectasis; Immunodeficiency; Diagnostic techniques and procedures;

D O I：

10.1007/s10405-013-0734-z

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

In bronchiectasis a vicious circle of small airway dilatation, impairment of local defence mechanisms, infection and endobronchial inflammation cause irreversible lung destruction with progressive deterioration of pulmonary function and quality of life. The main symptom is a chronic purulent cough and diagnosis is made on the basis of high-resolution computed tomography (HRCT). Once bronchiectasis has been confirmed it is vital that patients undergo further investigation to determine the underlying cause. The wide range of possible diseases requires a structured diagnostic approach. This paper reviews different causes of non-CF bronchiectasis (NCFB) and presents a diagnostic algorithm as well as therapeutic options. Our overview may serve as a guideline to paediatric and adult pulmonologists and contribute to improved diagnosis and treatment of NCFB patients in all age groups.

引用

页码：110 / 119

页数：10

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