Adipose depots differ in cellularity, adipokines produced, gene expression, and cell systems

被引:28
作者
Dodson, Michael V. [1 ]
Du, Min [1 ]
Wang, Songbo [1 ,2 ]
Bergen, Werner G. [3 ]
Fernyhough-Culver, Melinda [4 ]
Basu, Urmila [5 ]
Poulos, Sylvia P. [6 ]
Hausman, Gary J. [7 ]
机构
[1] Washington State Univ, Dept Anim Sci, Pullman, WA 99164 USA
[2] South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China
[3] Auburn Univ, Dept Anim Sci, Program Cellular & Mol Biosci, Auburn, AL 36849 USA
[4] Abitec Corp, Columbus, OH USA
[5] Univ Alberta, Edmonton, AB, Canada
[6] Akeso Hlth LLC, Decatur, GA USA
[7] Univ Georgia, Dept Anim & Dairy Sci, Athens, GA 30602 USA
关键词
adipose depots; cellularity; adipokine; adipocyte gene expression; adipose lineage cell;
D O I
10.4161/adip.28321
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The race to manage the health concerns related to excess fat deposition has spawned a proliferation of clinical and basic research efforts to understand variables including dietary uptake, metabolism, and lipid deposition by adipocytes. A full appreciation of these variables must also include a depot-specific understanding of content and location in order to elucidate mechanisms governing cellular development and regulation of fat deposition. Because adipose tissue depots contain various cell types, differences in the cellularity among and within adipose depots are presently being documented to ascertain functional differences. This has led to the possibility of there being, within any one adipose depot, cellular distinctions that essentially result in adipose depots within depots. The papers comprising this issue will underscore numerous differences in cellularity ( development, histogenesis, growth, metabolic function, regulation) of different adipose depots. Such information is useful in deciphering adipose depot involvement both in normal physiology and in pathology. Obesity, diabetes, metabolic syndrome, carcass composition of meat animals, performance of elite athletes, physiology/pathophysiology of aging, and numerous other diseases might be altered with a greater understanding of adipose depots and the cells that comprise them-including stem cells-during initial development and subsequent periods of normal/abnormal growth into senescence. Once thought to be dormant and innocuous, the adipocyte is emerging as a dynamic and influential cell and research will continue to identify complex physiologic regulation of processes involved in adipose depot physiology.
引用
收藏
页码:236 / 241
页数:6
相关论文
共 101 条
[1]  
Azain MJ, 2004, J ANIM SCI, V82, P916
[2]   Biology of leptin in the pig [J].
Barb, CR ;
Hausman, GJ ;
Houseknecht, KL .
DOMESTIC ANIMAL ENDOCRINOLOGY, 2001, 21 (04) :297-317
[3]   Effect of dietary conjugated linoleic acid on marbling and intramuscular adipocytes in pork [J].
Barnes, K. M. ;
Winslow, N. R. ;
Shelton, A. G. ;
Hlusko, K. C. ;
Azain, M. J. .
JOURNAL OF ANIMAL SCIENCE, 2012, 90 (04) :1142-U99
[4]   BODY-COMPOSITION OF ANIMALS TREATED WITH PARTITIONING AGENTS - IMPLICATIONS FOR HUMAN HEALTH [J].
BERGEN, WG ;
MERKEL, RA .
FASEB JOURNAL, 1991, 5 (14) :2951-2957
[5]  
Black LL, 2007, VET THER, V8, P272
[6]   Fetal growth factors and fetal nutrition [J].
Bloomfield, F. H. ;
Spiroski, Ana-Mishel ;
Harding, J. E. .
SEMINARS IN FETAL & NEONATAL MEDICINE, 2013, 18 (03) :118-123
[7]   Sex Differences in Metabolic and Adipose Tissue Responses to Juvenile-Onset Obesity in Sheep [J].
Bloor, Ian D. ;
Sebert, Sylvain P. ;
Saroha, Vivek ;
Gardner, David S. ;
Keisler, Duane H. ;
Budge, Helen ;
Symonds, Michael E. ;
Mahajan, Ravi P. .
ENDOCRINOLOGY, 2013, 154 (10) :3622-3631
[8]   Glucose-6-phosphate dehydrogenase and leptin are related to marbling differences among Limousin and Angus or Japanese Black x Angus steers [J].
Bonnet, M. ;
Faulconnier, Y. ;
Leroux, C. ;
Jurie, C. ;
Cassar-Malek, I. ;
Bauchart, D. ;
Boulesteix, P. ;
Pethick, D. ;
Hocquette, J. F. ;
Chilliard, Y. .
JOURNAL OF ANIMAL SCIENCE, 2007, 85 (11) :2882-2894
[9]   Aging, Depot Origin, and Preadipocyte Gene Expression [J].
Cartwright, Mark J. ;
Schlauch, Karen ;
Lenburg, Marc E. ;
Tchkonia, Tamara ;
Pirtskhalava, Tamar ;
Cartwright, Andrew ;
Thomou, Thomas ;
Kirkland, James L. .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2010, 65 (03) :242-251
[10]  
Chen Jie, 2009, Int J Stem Cells, V2, P76