A VERSATILE APPROACH TO THE SYNTHESIS OF COMBRETASTATINS

被引：10

作者：

MEDARDE, M

DECLAIRAC, RPL

LOPEZ, JL

SANFELICIANO, A

机构：

[1] Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Salamanca

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 08期

关键词：

D O I：

10.1021/np50110a002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new and versatile synthesis of combretastatins has been developed. Starring from commercially available materials, 2-phenyl-2-benzyl-1,3-dithianes were easily prepared and used as intermediates in the synthesis of several families of combretastatins. This approach facilitates the preparation of representative intermediates in a few steps, with or without an oxygenated function in the ethylenic residue. Many different analogues suitable for pharmacological evaluation can also be obtained from some of these intermediates.

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页码：1136 / 1144

页数：9

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