A NEUROPATHOLOGICAL STUDY OF A CASE OF LUPUS-ERYTHEMATOSUS WITH CHOREA

被引:14
作者
KUROE, K
KURAHASHI, K
NAKANO, I
MORIMATSU, Y
TAKEMORI, H
机构
[1] AOMORI PREFECTURAL CENT HOSP,DEPT NEUROL,AOMORI 030,JAPAN
[2] TOKYO METROPOLITAN INST NEUROSCI,DEPT NEUROPATHOL,TOKYO 183,JAPAN
[3] TOKYO METROPOLITAN INST NEUROSCI,DEPT CLIN NEUROPATHOL,TOKYO 183,JAPAN
关键词
LUPUS ERYTHEMATOSUS; CHOREA; BASAL GANGLIA; NEUROPATHOLOGICAL STUDY; NEURON LOSS IN THE STRIATUM; PURKINJE CELL LOSS; CNS LUPUS;
D O I
10.1016/0022-510X(94)90204-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neuropathological examination in a 48-year-women of SLE with chorea was performed. Histological examination of the putamen showed a widespread neuronal loss associated with reactive astrocyte proliferation and neuropil rarefaction at both sides. Disappearance of large neurons was more prominent than that of small ones. Although a few old and fresh microinfarcts were scattered in the same area, there was no significant pathological abnormality in small vessels. The caudate nuclei also showed a few irregular microinfarcts and spotty loss of neurons associated with reactive astrocytosis. These neuropathological changes might be related to the appearance of choreatic movement in patients with SLE.
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页码:59 / 63
页数:5
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