WHY DOES RECA PROTEIN HYDROLYZE ATP

被引：91

作者：

COX, MM

机构：

[1] M. M. Cox is at the Department of Biochemistry, University of Wisconsin, Madison, WI 53706

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 05期

关键词：

D O I：

10.1016/0968-0004(94)90025-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RecA is a DNA-dependent ATPase involved in DNA-strand repair. Most of the ATP hydrolysis that occurs in a RecA nucleoprotein filament is implicitly considered to be irrelevant in many current models for RecA-mediated DNA-strand exchange. However, preventing RecA from hydrolysing ATP alters its behavior, suggesting that ATP hydrolysis by RecA is more than incidental. This review explores recent results detailing the effects and rates of ATP hydrolysis by RecA, and models are proposed that permit us to account quantitatively for ATP consumption by this protein.

引用

页码：217 / 222

页数：6

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[1] BEAT THE CLOCK - PARADIGMS FOR NTPASES IN THE MAINTENANCE OF BIOLOGICAL FIDELITY [J].