BONE-MARROW NECROSIS FOLLOWING ALL-TRANS-RETINOIC ACID THERAPY FOR ACUTE PROMYELOCYTIC LEUKEMIA

被引：13

作者：

DREOSTI, LM ^{[1
]}

BEZWODA, W ^{[1
]}

GUNTER, K ^{[1
]}

机构：

[1] UNIV WITWATERSRAND,SCH MED,DEPT MED,JOHANNESBURG,SOUTH AFRICA

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 13卷 / 3-4期

关键词：

ACUTE PROMYELOCYTIC LEUKEMIA; ALL-TRANS RETINOIC ACID; BONE MARROW NECROSIS; BONE PAIN; M3; AML;

D O I：

10.3109/10428199409056301

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute promyelocytic leukaemia (APL) (FAB-M3) is associated with fatal haemorrhagic complications in 10 to 20% of patients. Recently ALL-Trans Retinoic acid (ALL-Trans RA) therapy has been used with rapid correction of the coagulopathy. Although minimal haematologic toxicity has been reported, a number of potentially serious side-effect have been described. We report a case of bone marrow necrosis occurring in a patient with APL treated with ALL-Trans RA. The possible relationship of this complication to retinoid therapy is discussed. This patient subsequently recovered and not only achieved complete remission but tolerated two cycles of chemotherapy without problems.

引用

页码：353 / 356

页数：4

共 5 条

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[3] Haung M.E., Ye H.C., Chen S.R., Chai J.R., Lu H.X., Zoha L., Gu L.J., Wang Z.I., Use of ALL-Transretinoic acid in the treatment of acute promyelocytic leukaemia, Blood, 72, pp. 567-572, (1988)
[4] Avvisati G., Wouter ten Cate J., Mandelli F., Annotation. Acute promyelocytic leukaemia, Br. J. Haematol., 81, pp. 315-320, (1992)
[5] Tallman M.S., Kwaan H.C., Reassessing the haemostatic disorder associated with acute promyelocytic leukaemia, Blood, 79, pp. 543-553, (1992)

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