LEWIS-ACID ASSISTED CYCLIZATION OF ARYLCYANOGUANIDINES TO 2,4-DIAMINOQUINAZOLINES

被引：7

作者：

JONES, ML ^{[1
]}

KUYPER, LF ^{[1
]}

STYLES, VL ^{[1
]}

CADDELL, JM ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO,CHEM DEV LABS,RES TRIANGLE PK,NC 27709

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 06期

关键词：

D O I：

10.1002/jhet.5570310668

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The mild preparation of N-cyano-N'-(1-H-indol-5-yl)guanidine and its cyclization to 1,3-diamino-7H-pyrrolo[3,2-f]quinazoline is described. Whereas previously reported methods of cyclization employed high temperatures to effect ring closure, we found that certain Lewis acids, such as boron trifluoride etherate, induce cyclization at moderate temperatures.

引用

页码：1681 / 1683

页数：3

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