IDENTIFICATION OF 4 FGF RECEPTOR GENES IN MEDAKA FISH (ORYZIAS-LATIPES)

被引：13

作者：

EMORI, Y

YASUOKA, A

SAIGO, K

机构：

[1] Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo

来源：

FEBS LETTERS | 1992年 / 314卷 / 02期

关键词：

MEDAKA; ORYZIAS-LATIPES; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; RT-PCR;

D O I：

10.1016/0014-5793(92)80968-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four types of cDNA clones encoding tyrosine kinases highly homologous to mammalian fibroblast growth factor receptors (FGF-R) were isolated from Medaka fish (Oryzias latipes) by the reverse transcription-polymerase chain reaction. Comparison of the four deduced amino acid sequences with four known mammalian FGF-Rs indicated that four FGF-R species corresponding to mammalian FGF-Rs exist universally in vertebrates including fishes, although FGF-R4 might have diverged sequences between fishes and mammals. Each of four FGF-R genes is transcribed to various extents as multiple mRNAs possibly by alternative splicing in adult fishes.

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收藏

页码：176 / 178

页数：3

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