DIFFERENCES BETWEEN VASORELAXANT RESPONSES OF THE CANINE AND HUMAN MESENTERIC-ARTERIES AND VEINS TO AMRINONE

被引：2

作者：

ITOH, H

SATO, Y

TANIGUCHI, K

NAKAGAWA, H

INUI, J

TAKEUCHI, J

机构：

[1] TOKYO MED & DENT UNIV,DEPT INTERNAL MED 2,BUNKYO KU,TOKYO 113,JAPAN

[2] YOSHITOMI PHARMACEUT IND LTD,RES LABS,SAITAMA 358,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 218卷 / 2-3期

关键词：

AMRINONE; DIBUTYRYL CAMP; MESENTERIC ARTERY; MESENTERIC VEIN;

D O I：

10.1016/0014-2999(92)90190-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Amrinone induced similar degrees of relaxation in human mesenteric arteries and veins contracted with KCl, but exerted a more potent vasodilator effect in canine mesenteric veins than in arteries. Dibutyryl cAMP had a stronger effect on KCl-induced contraction in canine mesenteric veins than in arteries. These results suggest that amrinone promotes a different vasodilating action in human and canine mesenteric vessels, possibly via different sensitivity to cAMP in each vascular smooth muscle.

引用

页码：347 / 349

页数：3

共 10 条

[1] OVERVIEW OF CARDIOVASCULAR PHYSIOLOGIC AND PHARMACOLOGIC ASPECTS OF SELECTIVE PHOSPHODIESTERASE PEAK-III INHIBITORS [J].