EXPRESSION OF THE FIBROBLAST GROWTH FACTOR-5 GENE IN THE MOUSE EMBRYO

被引：0

作者：

HAUB, O ^{[1
]}

GOLDFARB, M ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,630 W 168TH ST,NEW YORK,NY 10032

来源：

DEVELOPMENT | 1991年 / 112卷 / 02期

关键词：

MOUSE EMBRYO; FGF-5; FIBROBLAST GROWTH FACTOR-5; RNA; INSITU HYBRIDIZATION;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fibroblast growth factors (FGFs) are structurally related mitogens that can regulate the differentiation of a wide variety of cells. As a step towards elucidating the developmental roles played by one of these factors, we have used in situ hybridization methods to examine expression of the murine Fgf-5 gene during embryogenesis. Fgf-5 RNA was detected at seven distinct sites in the developing mouse embryo: (1) postimplantation epiblast (embryonic day 5 1/4-7 1/2), (2) lateral splanchnic mesoderm (E9 1/2-10 1/2), (3) lateral somatic mesoderm (E10 1/2-12 1/2), (4) myotomes (E10 1/2-12 1/2), (5) mastication muscle (E11 1/2-14 1/2), (6) limb mesenchyme (E12 1/2-14 1/2), and (7) acoustic ganglion (E12 1/2-14 1/2). At several of these sites, expression is spatially restricted within the tissues. We offer several hypotheses regarding the roles of FGF-5 in murine development.

引用

页码：397 / &

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