EXPRESSION OF THE FIBROBLAST GROWTH FACTOR-5 GENE IN THE MOUSE EMBRYO

被引：0
|
作者：
HAUB, O [1 ]
GOLDFARB, M [1 ]
机构：
[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,630 W 168TH ST,NEW YORK,NY 10032
来源：
DEVELOPMENT | 1991年 / 112卷 / 02期
关键词：
MOUSE EMBRYO; FGF-5; FIBROBLAST GROWTH FACTOR-5; RNA; INSITU HYBRIDIZATION;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Fibroblast growth factors (FGFs) are structurally related mitogens that can regulate the differentiation of a wide variety of cells. As a step towards elucidating the developmental roles played by one of these factors, we have used in situ hybridization methods to examine expression of the murine Fgf-5 gene during embryogenesis. Fgf-5 RNA was detected at seven distinct sites in the developing mouse embryo: (1) postimplantation epiblast (embryonic day 5 1/4-7 1/2), (2) lateral splanchnic mesoderm (E9 1/2-10 1/2), (3) lateral somatic mesoderm (E10 1/2-12 1/2), (4) myotomes (E10 1/2-12 1/2), (5) mastication muscle (E11 1/2-14 1/2), (6) limb mesenchyme (E12 1/2-14 1/2), and (7) acoustic ganglion (E12 1/2-14 1/2). At several of these sites, expression is spatially restricted within the tissues. We offer several hypotheses regarding the roles of FGF-5 in murine development.
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页码：397 / &
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