DISPARATE REGULATION OF INTERLEUKIN-8 GENE-EXPRESSION FROM BLOOD MONOCYTES, ENDOTHELIAL-CELLS, AND FIBROBLASTS BY INTERLEUKIN-4

被引：44

作者：

STANDIFORD, TJ ^{[1
]}

STRIETER, RM ^{[1
]}

KASAHARA, K ^{[1
]}

KUNKEL, SL ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT PATHOL,ANN ARBOR,MI 48109

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)91178-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role(s) of novel chemotactic cytokines as mediators in the pathogenesis of many acute and chronic disease states is becoming increasingly apparent. One of these cytokines, interleukin 8, is a product of both immune and non-immune cells. In this manuscript, we describe the suppression of IL-8 gene expression from stimulated monocytes by IL-4, while IL-4 had no suppressive effects on IL-8 gene expression from stimulated fibroblasts and endothelial cells. Our data suggest that IL-4 may function as an endogenous regulator of monocyte cytokine expression, including the chemotactic cytokine IL-8. © 1990.

引用

页码：531 / 536

页数：6

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