FINE MAPPING OF HUMAN 5S RIBOSOMAL-RNA GENES TO CHROMOSOME 1Q42.11-]Q42.13

被引：32
作者：
SORENSEN, PD
LOMHOLT, B
FREDERIKSEN, S
TOMMERUP, N
机构：
[1] PANUM INST,DEPT BIOCHEM B,BLEGDAMSVEJ 3,DK-2200 COPENHAGEN N,DENMARK
[2] UNIV COPENHAGEN,PANUM INST,INST MED GENET,DK-2200 COPENHAGEN,DENMARK
[3] JOHN F KENNEDY INST,DEPT MED GENET,GLOSTRUP,DENMARK
来源：
CYTOGENETICS AND CELL GENETICS | 1991年 / 57卷 / 01期
关键词：
D O I：
10.1159/000133107
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The human 5S rRNA genes have been localized by in situ hybridization to metaphase chromosomes. Tritiated RNA probes were made by transcription from 2,300-bp and 638-bp DNA fragments containing an isolated human 5S rRNA gene. Hybridization to metaphase spreads from a balanced reciprocal translocation carrier, 46,XX,t(1;7)(q42.13;p11.1), showed that the 5S rRNA genes were entirely localized on the normal and the derivative chromosome 1. This narrows the chromosome position of the major fraction of 5S rRNA genes and pseudogenes to the region 1q42.11 --> q42.13.
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页码：26 / 29
页数：4
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