The open field test was studied as a predictive behavioural criterion of resistance to emotional stress. Emotional stress mas induced in Wistar rats by Immobilization with simultaneous electrical skin stimulation 3 days after behavioural testing. Severity of stress was evaluated by the rate of survival and changes in the weight of thymus and adrenals. Rats which displayed longer latencies of the first movement in the open field and of crossing the central areas, lower locomotor and exploratory activity, higher rate of defecation had lower survival rate and more pronounced adrenal hypertrophy in stress.
机构:Departement de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique, Unite de Recherche Associee 606, Faculte de Pharmacie, Lyon
JULIEN, C
SACQUET, J
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机构:Departement de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique, Unite de Recherche Associee 606, Faculte de Pharmacie, Lyon
SACQUET, J
KANDZA, P
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机构:Departement de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique, Unite de Recherche Associee 606, Faculte de Pharmacie, Lyon
KANDZA, P
SU, DF
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机构:Departement de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique, Unite de Recherche Associee 606, Faculte de Pharmacie, Lyon
SU, DF
VINCENT, M
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机构:Departement de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique, Unite de Recherche Associee 606, Faculte de Pharmacie, Lyon
VINCENT, M
BARRES, C
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机构:Departement de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique, Unite de Recherche Associee 606, Faculte de Pharmacie, Lyon