AN IN-SITU HYBRIDIZATION STUDY ON INTERLEUKIN-1-BETA MESSENGER-RNA INDUCED BY TRANSIENT FOREBRAIN ISCHEMIA IN THE RAT-BRAIN

被引：98
作者：
YABUUCHI, K
MINAMI, M
KATSUMATA, S
YAMAZAKI, A
SATOH, M
机构：
[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT MOLEC PHARMACOL,KYOTO 60601,JAPAN
[2] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KYOTO 60601,JAPAN
[3] NIPPON SHINYAKU CO LTD,RES LABS,KYOTO,JAPAN
来源：
MOLECULAR BRAIN RESEARCH | 1994年 / 26卷 / 1-2期
关键词：
TRANSIENT FOREBRAIN ISCHEMIA; INTERLEUKIN-1-BETA; IN SITU HYBRIDIZATION; RAT;
D O I：
10.1016/0169-328X(94)90084-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Expression of interleukin-1 beta (IL-1 beta) mRNA in the rat brain after transient forebrain ischemia was investigated by in situ hybridization histochemistry. Thirty min after the start of recirculation, IL-1 beta mRNA was induced in the several brain regions, including the olfactory bulb, cerebral cortex, hippocampus, striatum and thalamus where neuronal degeneration was reported to be observed after transient forebrain ischemia. The hybridization signals were observed both on the glial cells and around the vascular walls.
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页码：135 / 142
页数：8
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