INVOLVEMENT OF RET ONCOGENE IN HUMAN TUMORS - SPECIFICITY OF RET ACTIVATION TO THYROID-TUMORS

被引：71

作者：

SANTORO, M

SABINO, N

ISHIZAKA, Y

USHIJIMA, T

CARLOMAGNO, F

CERRATO, A

GRIECO, M

BATTAGLIA, C

MARTELLI, ML

PAULIN, C

FABIEN, N

SUGIMURA, T

FUSCO, A

NAGAO, M

机构：

[1] UNIV REGGIO CALABRIA,FAC MED & CHIRURG CATANZARO,DIPARTIMENTO MED SPERIMENTALE & CLIN,I-88100 CATANZARO,ITALY

[2] NATL CANC CTR,RES INST,DIV CARCINOGENESIS,CHUO KU,TOKYO 104,JAPAN

[3] CTR HOSP LYON SUD,HISTOL & CYTOL LAB,F-69310 PIERRE BENITE,FRANCE

[4] FAC MED LYON SUD,CNRS,URA 1454,F-69600 OULLINS,FRANCE

[5] UNIV NAPLES,FAC MED & CHIRURG 2,IST ANAT CHIRURG & SCI GASTEENTOL,I-80131 NAPLES,ITALY

来源：

BRITISH JOURNAL OF CANCER | 1993年 / 68卷 / 03期

关键词：

D O I：

10.1038/bjc.1993.370

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-thyroid neoplasis were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10%-20% of human thyroid papillary carcinomas. None of 528 non-thyroid tumours showed rearrangement of the RET proto-oncogene, whereas three out of 30 thyroid papillary carcinomas were positive for RET activation. Therefore the activation of RET seems to be a somatic cell mutation specific to human thyroid carcinomas.

引用

页码：460 / 464

页数：5

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