YEAST MULTIDRUG-RESISTANCE - THE PDR NETWORK

被引：229

作者：

BALZI, E ^{[1
]}

GOFFEAU, A ^{[1
]}

机构：

[1] UNIV CATHOLIQUE LOUVAIN, UNITE BIOCHIM PHYSIOL, B-1348 LOUVAIN, BELGIUM

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1995年 / 27卷 / 01期

关键词：

MULTIDRUG RESISTANCE; MDR; PDR; ABC MEMBRANE PROTEINS; TRANSCRIPTION REGULATION;

D O I：

10.1007/BF02110333

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

This minireview describes a network of genes involved in multiple drug resistance of the yeast S. cer cerevisiae. The transcription regulators, PDR1, PDR3, PDR7, and PDR9 control the expression of the gene PDR5, encoding a membrane protein of the ATP-binding-cassette superfamily and functioning as a drug extrusion pump. Next to PDR5, several other target genes, encoding membrane pumps of the ABC type, such as SNQ2, STE6, PDR10, PDR11, YOR1, but also other membrane-associated (such as GAS1, D4405) or soluble proteins (such as G3PD), involved or not in multidrug resistance, are found to be controlled by PDR1. On another side, the PDR3 regulator participates with its homolog PDR1 to co- and auto-regulation circuits of yeast multidrug resistance.

引用

页码：71 / 76

页数：6

共 30 条

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