ASSOCIATION BETWEEN PROTO-ONCOPROTEIN REL AND TATA-BINDING PROTEIN MEDIATES TRANSCRIPTIONAL ACTIVATION BY NF-KAPPA-B

被引：153
作者：
KERR, LD
RANSONE, LJ
WAMSLEY, P
SCHMITT, MJ
BOYER, TG
ZHOU, Q
BERK, AJ
VERMA, IM
机构：
[1] SALK INST BIOL STUDIES,MOLEC BIOL & VIROL LAB,SAN DIEGO,CA 92138
[2] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,DEPT MICROBIOL & MOLEC GENET,LOS ANGELES,CA 90024
来源：
NATURE | 1993年 / 365卷 / 6445期
关键词：
D O I：
10.1038/365412a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the kappaB site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fall to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between kappaB enhancer binding proteins and basal transcription factors which leads to enhanced transcription.
引用
收藏
页码：412 / 419
页数：8
相关论文
共 50 条
[1]   A NOVEL MITOGEN-INDUCIBLE GENE-PRODUCT RELATED TO P50/P105-NF-KAPPA-B PARTICIPATES IN TRANSACTIVATION THROUGH A KAPPA-B SITE [J].
BOURS, V ;
BURD, PR ;
BROWN, K ;
VILLALOBOS, J ;
PARK, S ;
RYSECK, RP ;
BRAVO, R ;
KELLY, K ;
SIEBENLIST, U .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (02) :685-695
[2]   THE MOUSE C-REL PROTEIN HAS AN N-TERMINAL REGULATORY DOMAIN AND A C-TERMINAL TRANSCRIPTIONAL TRANSACTIVATION DOMAIN [J].
BULL, P ;
MORLEY, KL ;
HOEKSTRA, MF ;
HUNTER, T ;
VERMA, IM .
MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (10) :5473-5485
[3]   TFIID CAN BE RATE LIMITING INVIVO FOR TATA-CONTAINING, BUT NOT TATA-LACKING, RNA POLYMERASE-II PROMOTERS [J].
COLGAN, J ;
MANLEY, JL .
GENES & DEVELOPMENT, 1992, 6 (02) :304-315
[4]   FACTORS INVOLVED IN SPECIFIC TRANSCRIPTION BY MAMMALIAN RNA POLYMERASE-II - PURIFICATION AND ANALYSIS OF TRANSCRIPTION FACTOR-IIA AND IDENTIFICATION OF TRANSCRIPTION FACTOR-IIJ [J].
CORTES, P ;
FLORES, O ;
REINBERG, D .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (01) :413-421
[5]  
Coulombe Benoit, 1992, Gene Expression, V2, P99
[6]   ISOLATION OF COACTIVATORS ASSOCIATED WITH THE TATA-BINDING PROTEIN THAT MEDIATE TRANSCRIPTIONAL ACTIVATION [J].
DYNLACHT, BD ;
HOEY, T ;
TJIAN, R .
CELL, 1991, 66 (03) :563-576
[7]   CLONING OF THE P50 DNA-BINDING SUBUNIT OF NF-KAPPA-B - HOMOLOGY TO REL AND DORSAL [J].
GHOSH, S ;
GIFFORD, AM ;
RIVIERE, LR ;
TEMPST, P ;
NOLAN, GP ;
BALTIMORE, D .
CELL, 1990, 62 (05) :1019-1029
[8]  
GILMORE TD, 1992, CANCER SURV, V15, P69
[9]   TISSUE-SPECIFIC INVITRO TRANSCRIPTION FROM THE MOUSE ALBUMIN PROMOTER [J].
GORSKI, K ;
CARNEIRO, M ;
SCHIBLER, U .
CELL, 1986, 47 (05) :767-776
[10]   TRANSCRIPTION - RIDING HIGH ON THE TATA BOX [J].
GREENBLATT, J .
NATURE, 1992, 360 (6399) :16-17
12345