SIMULATION OF THE DIFFERENTIAL ADHESION DRIVEN REARRANGEMENT OF BIOLOGICAL CELLS

被引：567

作者：

GLAZIER, JA ^{[1
]}

GRANER, F ^{[1
]}

机构：

[1] UNIV NOTRE DAME,DEPT PHYS,NOTRE DAME,IN 46556

来源：

PHYSICAL REVIEW E | 1993年 / 47卷 / 03期

关键词：

D O I：

10.1103/PhysRevE.47.2128

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

We show that differential adhesion with fluctuations is sufficient to explain a wide variety of cell rearrangement, by using the extended large-Q Potts model with differential adhesivity to simulate different biological phenomena. Different values of relative surface energies correspond to different biological cases, including complete and partial cell sorting, checkerboard, position reversal, and dispersal. We examine the convergence and temperature dependence of the simulation and distinguish spontaneous, neutral, and activated processes by performing simulations at different temperatures. We discuss the biological and physical implications of our quantitative results.

引用

页码：2128 / 2154

页数：27

共 89 条

[71] ON MECHANISM OF TISSUE RECONSTRUCTION BY DISSOCIATED CELLS .3. FREE ENERGY RELATIONS AND REORGANIZATION OF FUSED, HETERONOMIC TISSUE FRAGMENTS [J].