A QSPR STUDY OF 3-(PHTHALIMIDOALKYL)-PYRAZOLIN-5-ONES

Several QSPR models with topological indices are proposed for predicting physical properties of newly prepared 3-(phthalimidoalkyl)-pyrazolin-5-ones. Four topological indices were used. These are the Wiener index, the valence connectivity index, the Balaban index and the information-theoretic index. The best QSPR models were obtained using the Wiener index and the valence connectivity index. The Balaban index and the information-theoretic index produced less accurate models. QSPR models based on combination of indices appear also to be reliable.