DISTINCT PATTERNS OF T-CELL AND B-CELL IMMUNITY TO RESPIRATORY SYNCYTIAL VIRUS-INDUCED BY INDIVIDUAL VIRAL-PROTEINS

被引：71

作者：

ALWAN, WH ^{[1
]}

OPENSHAW, PJM ^{[1
]}

机构：

[1] ST MARYS HOSP, SCH MED, DEPT MED, NORFOLK PL, LONDON W2 1PG, ENGLAND

来源：

VACCINE | 1993年 / 11卷 / 04期

基金：

英国惠康基金;

关键词：

RESPIRATORY SYNCYTIAL VIRUS; T-CELL IMMUNITY; B-CELL IMMUNITY; VIRAL PROTEINS;

D O I：

10.1016/0264-410X(93)90284-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice were infected with respiratory syncytial (RS) virus or with recombinant vaccinia viruses (rVV) expressing individual RS virus proteins. rVV-G, rVV-F and, to a lesser extent, rVV-P induced ELISA-binding anti-RS virus antibodies; those induced by rVV-P were non-neutralizing. Different antigens induced helper T cells with distinct cytokine secretion profiles: some released IL-2, and others predominantly IL-4 and 5. Virus-specific cytotoxicity was induced by infection with RS virus, rVV-F or rVV-22K. Different RS virus proteins (given in the same route and form) therefore prime for functionally distinct T-cell activities. These patterns of virus-specific immunity may help explain the pathogenicity of RS virus vaccines, and help in the design of protective, non-pathogenic vaccines in the future.

引用

页码：431 / 437

页数：7

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