APPLICATION OF 3-(2-FUROYL)QUINOLINE-2-CARBALDEHYDE AS A FLUOROGENIC REAGENT FOR THE ANALYSIS OF PRIMARY AMINES BY LIQUID-CHROMATOGRAPHY WITH LASER-INDUCED FLUORESCENCE DETECTION

被引：50

作者：

BEALE, SC ^{[1
]}

HSIEH, YZ ^{[1
]}

WIESLER, D ^{[1
]}

NOVOTNY, M ^{[1
]}

机构：

[1] INDIANA UNIV,DEPT CHEM,BLOOMINGTON,IN 47405

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 499卷

关键词：

D O I：

10.1016/S0021-9673(00)97002-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

3-(2-Furoyl)quinoline-2-carbaldehyde (FQCA) has been synthesized and characterized as a fluorogenic derivatizing reagent for liquid chromatography. The reagent forms highly fluorescent isoindoles upon reaction with primary amines. The spectral properties and optimum reaction conditions for the formation of isoindoles have been investigated. The utility of FQCA for the high-sensitivity analysis of amino acids by laser-induced fluorescence with an argon-ion laser is demonstrated. © 1990.

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页码：579 / 587

页数：9

相关论文

共 24 条

[1] FLUORESCENCE REAGENTS FOR HIGH-SENSITIVITY CHROMATOGRAPHIC MEASUREMENTS OF PRIMARY AMINES [J].

BEALE, SC ;

SAVAGE, JC ;

WIESLER, D ;

WIETSTOCK, SM ;

NOVOTNY, M .

ANALYTICAL CHEMISTRY, 1988, 60 (17) :1765-1769

[2]

BEALE SC, 1989, TALANTA, V36, P322

[3]

BORSCHE W, 1943, CHEM BER, V76, P1099

[4] STUDIES ON REACTION OF FLUORESCAMINE WITH PRIMARY AMINES [J].

DE BERNARDO, S ;

WEIGELE, M ;

TOOME, V ;

MANHART, K ;

LEIMGRUBER, W ;

BOHLEN, P ;

STEIN, S ;

UDENFRIEND, S .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1974, 163 (01) :390-399

[5] NAPHTHALENE-2,3-DICARBOXALDEHYDE CYANIDE ION - A RATIONALLY DESIGNED FLUOROGENIC REAGENT FOR PRIMARY AMINES [J].

DEMONTIGNY, P ;

STOBAUGH, JF ;

GIVENS, RS ;

CARLSON, RG ;

SRINIVASACHAR, K ;

STERNSON, LA ;

HIGUCHI, T .

ANALYTICAL CHEMISTRY, 1987, 59 (08) :1096-1101

[6] PROFILING OF AMINO-ACIDS IN BODY-FLUIDS AND TISSUES BY MEANS OF LIQUID-CHROMATOGRAPHY [J].

DEYL, Z ;

HYANEK, J ;

HORAKOVA, M .

JOURNAL OF CHROMATOGRAPHY, 1986, 379 :177-250

[7] FUSED-SILICA PACKED MICROCOLUMNS AS MICROPREPARATIVE TOOLS IN PROTEIN ANALYTICAL STUDIES [J].

FLURER, C ;

BORRA, C ;

BEALE, S ;

NOVOTNY, M .

ANALYTICAL CHEMISTRY, 1988, 60 (17) :1826-1829

[8] SEPARATION OF PROTEINS BY MICROCOLUMN LIQUID-CHROMATOGRAPHY BASED ON THE REVERSED-PHASE AND SIZE-EXCLUSION PRINCIPLES [J].

FLURER, CL ;

BORRA, C ;

ANDREOLINI, F ;

NOVOTNY, M .

JOURNAL OF CHROMATOGRAPHY, 1988, 448 (01) :73-86

[9] 7-CHLORO-4-NITROBENZO-2-OXA-1,3-DIAZOLE - A NEW FLUORIGENIC REAGENT FOR AMINO ACIDS AND OTHER AMINES [J].

GHOSH, PB ;

WHITEHOUSE, MW .

BIOCHEMICAL JOURNAL, 1968, 108 (01) :155-+

[10] LASER FLUORIMETRY FOR CAPILLARY COLUMN LIQUID-CHROMATOGRAPHY - HIGH-SENSITIVITY DETECTION OF DERIVATIZED BIOLOGICAL COMPOUNDS [J].

GLUCKMAN, J ;

SHELLY, D ;

NOVOTNY, M .

JOURNAL OF CHROMATOGRAPHY, 1984, 317 (DEC) :443-453