Pomegranate for Your Cardiovascular Health

被引:22
作者
Aviram, Michael [1 ]
Rosenblat, Mira
机构
[1] Technion Israel Inst Technol, Rappaport Fac Med, Lipid Res Lab, Haifa, Israel
关键词
Atherosclerosis; pomegranate; antioxidant; polyphenols; macrophages; lipoproteins; (LDL; HDL);
D O I
10.5041/RMMJ.10113
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pomegranate is a source of some very potent antioxidants (tannins, anthocyanins) which are considered to be also potent anti-atherogenic agents. The combination of the above unique various types of pomegranate polyphenols provides a much wider spectrum of action against several types of free radicals. Indeed, pomegranate is superior in comparison to other antioxidants in protecting low-density lipoprotein (LDL, "the bad cholesterol") and high-density lipoprotein (HDL, "the good cholesterol") from oxidation, and as a result it attenuates atherosclerosis development and its consequent cardiovascular events. Pomegranate antioxidants are not free, but are attached to the pomegranate sugars, and hence were shown to be beneficial even in diabetic patients. Furthermore, pomegranate antioxidants are unique in their ability to increase the activity of the HDL-associated paraoxonase 1 (PON1), which breaks down harmful oxidized lipids in lipoproteins, in macrophages, and in atherosclerotic plaques. Finally, unique pomegranate antioxidants beneficially decrease blood pressure. All the above beneficial characteristics make the pomegranate a uniquely healthy fruit.
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页数:12
相关论文
共 59 条
[1]   One Enzyme, Two Functions PON2 PREVENTS MITOCHONDRIAL SUPEROXIDE FORMATION AND APOPTOSIS INDEPENDENT FROM ITS LACTONASE ACTIVITY [J].
Altenhoefer, Sebastian ;
Witte, Ines ;
Teiber, John F. ;
Wilgenbus, Petra ;
Pautz, Andrea ;
Li, Huige ;
Daiber, Andreas ;
Witan, Heidrun ;
Clement, Albrecht M. ;
Foerstermann, Ulrich ;
Horke, Sven .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (32) :24398-24403
[2]   Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions - PON1 esterase and peroxidase-like activities [J].
Aviram, M ;
Hardak, E ;
Vaya, J ;
Mahmood, S ;
Milo, S ;
Hoffman, A ;
Billicke, S ;
Draganov, D ;
Rosenblat, M .
CIRCULATION, 2000, 101 (21) :2510-2517
[3]   Paraoxonases 1, 2, and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development [J].
Aviram, M ;
Rosenblat, M .
FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (09) :1304-1316
[4]   Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation [J].
Aviram, M ;
Rosenblat, M ;
Gaitini, D ;
Nitecki, S ;
Hoffman, A ;
Dornfeld, L ;
Volkova, N ;
Presser, D ;
Attias, J ;
Liker, H ;
Hayek, T .
CLINICAL NUTRITION, 2004, 23 (03) :423-433
[5]  
Aviram M, 2002, DRUG EXP CLIN RES, V28, P49
[6]   Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants [J].
Aviram, M ;
Rosenblat, M ;
Billecke, S ;
Erogul, J ;
Sorenson, R ;
Bisgaier, CL ;
Newton, RS ;
La Du, B .
FREE RADICAL BIOLOGY AND MEDICINE, 1999, 26 (7-8) :892-904
[7]   Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions - A possible peroxidative role for paraoxonase [J].
Aviram, M ;
Rosenblat, M ;
Bisgaier, CL ;
Newton, RS ;
Primo-Parmo, SL ;
La Du, BN .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (08) :1581-1590
[8]   Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure [J].
Aviram, M ;
Dornfeld, L .
ATHEROSCLEROSIS, 2001, 158 (01) :195-198
[9]  
Aviram M, 2000, AM J CLIN NUTR, V71, P1062
[10]  
Aviram M, 2003, REDOX GENOME INTERAC, P57