Inflammaging - Aging as a Consequence of Chronic Inflammation: Example of Padma 28

Inflammaging describes a chronic, systemic inflammatory state that results from agerelated changes of the immune system. It is thought to be the basis of various chronic inflammatory diseases of old age, e.g., atherosclerosis, diabetes mellitus type 2, as well as Alzheimer's disease and cancer. The development of this proinflammatory milieu and its progression is accelerated and in some cases aggravated by oxidative stress. Complex phytotherapeutics (such as Padma 28) act as pleiotropic compounds, suited to stop these pathogenic processes at different sites of action. Besides the clinical effect of Padma 28, different mechanisms of action of the preparation in atherosclerosis are well documented and research results support the hypothesis that a multi-target approach with herbal multicompounds may offer a valuable contribution to new prevention and treatment strategies in chronic inflammatory conditions. Herbal multicompounds are therefore well suited to positively influence "inflammaging" conditions and to slow down the development of ensuing diseases, in some cases also preventing them.