Facile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in Ionic Liquid and study of their antibacterial activities

被引：0

作者：

Bazgir, Ayoob ^{[1
]}

Azimi, Seyyedeh Cobra ^{[2
]}

机构：

[1] Shahid Beheshti Univ, Dept Chem, Tehran, Iran

[2] Islamic Azad Univ, Young Researchers Club, Rasht Branch, Rasht, Iran

来源：

IRANIAN JOURNAL OF CATALYSIS | 2013年 / 3卷 / 01期

关键词：

Ionic liquid; Pyrimido[4,5-dJpyrimidine-2,4-dione; 6-Amino-uracil; Antibacterial activities;

D O I：

暂无

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIm]Br) under solvent-free conditions is reported. The presented method is benefited from operational simplicity, simple workup and reusability of ionic liquid. These products were evaluated in vitro for their antibacterial activities.

引用

页码：21 / 26

页数：6

共 31 条

[1]

Bamoniri A, 2012, IRAN J CATAL, V2, P185

[2]

CAMPAIGNE E, 1969, Journal of Medicinal Chemistry, V12, P339

[3] Ionic liquid [bmim][BF4] acts as solvent and promoter for synthesis of halo-containing N-arylphthalimides [J].