Ancillary Testing in Lung Cancer Diagnosis

被引:11
作者
Dubinski, William [1 ,2 ]
Leighl, Natasha B. [3 ]
Tsao, Ming-Sound [1 ,2 ]
Hwang, David M. [1 ,2 ]
机构
[1] Univ Hlth Network, Toronto Gen Hosp, Dept Pathol, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada
[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada
[3] Univ Hlth Network, Princess Margaret Hosp, Dept Med Oncol & Hematol, Toronto, ON M5G 2M9, Canada
关键词
D O I
10.1155/2012/249082
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
The pathologic diagnosis of lung cancer historically has relied primarily on morphologic features of tumors in histologic sections. With the emergence of new targeted therapies, the pathologist is called upon increasingly to provide not only accurate typing of lung cancers, but also to provide prognostic and predictive information, based on a growing number of ancillary tests, that may have significant impact on patient management. This review provides an overview of ancillary tests currently used in the pathologic diagnosis of lung cancer, with a focus on immunohistochemistry and molecular diagnostics.
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页数:8
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共 56 条
[1]  
Ahrendt SA, 2001, CANCER, V92, P1525, DOI 10.1002/1097-0142(20010915)92:6<1525::AID-CNCR1478>3.0.CO
[2]  
2-H
[3]   Ki-67 immunoreactivity in the differential diagnosis of pulmonary neuroendocrine neoplasms in specimens with extensive crush artifact [J].
Aslan, DL ;
Gulbahce, HE ;
Pambuccian, SE ;
Manivel, JC ;
Jessurun, J .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2005, 123 (06) :874-878
[4]   Thyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) gene regulation in the lung [J].
Boggaram, Vijay .
CLINICAL SCIENCE, 2009, 116 (1-2) :27-35
[5]   Biological markers for non-small cell lung cancer patient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy [J].
Bunn, Paul A., Jr. ;
Dziadziuszko, Rafal ;
Varella-Garcia, Marileila ;
Franklin, WilburA. ;
Witta, Samir E. ;
Kelly, Karen ;
Hirsch, Fred R. .
CLINICAL CANCER RESEARCH, 2006, 12 (12) :3652-3656
[6]   Increased MET Gene Copy Number Negatively Affects Survival of Surgically Resected Non-Small-Cell Lung Cancer Patients [J].
Cappuzzo, Federico ;
Marchetti, Antonio ;
Skokan, Margaret ;
Rossi, Elisa ;
Gajapathy, Sujatha ;
Felicioni, Lara ;
del Grammastro, Maela ;
Sciarrotta, Maria Grazia ;
Buttitta, Fiamma ;
Incarbone, Matteo ;
Toschi, Luca ;
Finocchiaro, Giovanna ;
Destro, Annarita ;
Terracciano, Luigi ;
Roncalli, Massimo ;
Alloisio, Marco ;
Santoro, Armando ;
Varella-Garcia, Marileila .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (10) :1667-1674
[7]   A five-gene signature and clinical outcome in non-small-cell lung cancer [J].
Chen, Hsuan-Yu ;
Yu, Sung-Liang ;
Chen, Chun-Houh ;
Chang, Gee-Chen ;
Chen, Chih-Yi ;
Yuan, Ang ;
Cheng, Chiou-Ling ;
Wang, Chien-Hsun ;
Terng, Harn-Jing ;
Kao, Shu-Fang ;
Chan, Wing-Kai ;
Li, Han-Ni ;
Liu, Chun-Chi ;
Singh, Sher ;
Chen, Wei J. ;
Chen, Jeremy J. W. ;
Yang, Pan-Chyr .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (01) :11-20
[8]   c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention [J].
Christensen, JG ;
Burrows, J ;
Salgia, R .
CANCER LETTERS, 2005, 225 (01) :1-26
[9]   Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study [J].
Ciuleanu, Tudor ;
Brodowicz, Thomas ;
Zielinski, Christoph ;
Kim, Joo Hang ;
Krzakowski, Maciej ;
Laack, Eckart ;
Wu, Yi-Long ;
Bover, Isabel ;
Begbie, Stephen ;
Tzekova, Valentina ;
Cucevic, Branka ;
Pereira, Jose Rodrigues ;
Yang, Sung Hyun ;
Madhavan, Jayaprakash ;
Sugarman, Katherine P. ;
Peterson, Patrick ;
John, William J. ;
Krejcy, Kurt ;
Belani, Chandra P. .
LANCET, 2009, 374 (9699) :1432-1440
[10]   Molecular predictive and prognostic markers in non-small-cell lung cancer [J].
Coate, Linda E. ;
John, Thomas ;
Tsao, Ming-Sound ;
Shepherd, Frances A. .
LANCET ONCOLOGY, 2009, 10 (10) :1001-1010