Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment

被引：54

作者：

Gurion, R. ^{[1
]}

Lehman, T. J. A. ^{[2
]}

Moorthy, L. N. ^{[3
]}

机构：

[1] Univ Hosp Case Med Ctr, Rainbow Babies & Childrens Hosp, Div Pediat Rheumatol, Cleveland, OH 44106 USA

[2] Cornell Univ, Hosp Special Surg & Clin Pediat, Weill Med Ctr, Div Pediat Rheumatol, New York, NY 10021 USA

[3] Univ Med & Dent, NJ Robert Wood Johnson Med Sch, Dept Pediat, Div Pediat Rheumatol, 591 French St, New Brunswick, NJ 08901 USA

来源：

INTERNATIONAL JOURNAL OF INFLAMMATION | 2012年 / 2012卷

关键词：

D O I：

10.1155/2012/271569

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic juvenile idiopathic arthritis (sJIA) constitutes a small part of juvenile idiopathic arthritis (JIA), yet has a disproportionally higher rate of mortality. Despite being grouped under JIA, it is considered to be a multifactorial autoinflammatory disease. The objective of this paper is to review the epidemiology, pathogenesis, genetics, clinical manifestations, complications, therapy, prognosis, and outcome of sJIA. The presentation and clinical manifestations of sJIA have not changed much in the past several decades, but the collective understanding of the pathogenesis and the development of new targeted therapies (particularly the biologic agents) have transformed and improved the disease outcome for children with sJIA.

引用

页数：16

共 211 条

[1] Update on the pathogenesis and treatment of systemic onset juvenile rheumatoid arthritis [J].