IFN-GAMMA-INDUCES A PHOSPHOLIPASE-D DEPENDENT TRIPHASIC ACTIVATION OF PROTEIN-KINASE-C IN ENDOTHELIAL-CELLS

被引：12
|
作者：
MATTILA, P
RENKONEN, R
机构：
[1] Department of Bacteriology and Immunology, University of Helsinki, Helsinki
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 03期
关键词：
D O I：
10.1016/0006-291X(92)90278-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The IFN-γ linked PKC activation in endothelial cells was analysed. It was shown that IFN-γ activates PKC in three transient and separate cycles within the first 60 minutes after IFN-γ stimulation. Before each PKC activation there was an increase in DAG level. IP3, phosphocholine and choline productions were measured to determine the origin of DAG. Neither of the PLC products, IP3 or phosphocholine, were released after IFN-γ stimulation. On the other hand the PLD products choline and PA were released before all the three activation cycles of PKC. © 1992.
引用
收藏
页码：1732 / 1738
页数：7
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