EFFECTS OF INTERLEUKIN-1 AND INTERLEUKIN-6 ON METALLOTHIONEIN AND AMYLOID PRECURSOR PROTEIN EXPRESSION IN HUMAN NEUROBLASTOMA-CELLS - EVIDENCE THAT INTERLEUKIN-6 POSSIBLY ACTS VIA A RECEPTOR DIFFERENT FROM THE 80-KDA INTERLEUKIN-6 RECEPTOR

被引:24
作者
BAUER, J
GANTER, U
ABEL, J
STRAUSS, S
JONAS, U
WEISS, R
GEBICKEHAERTER, P
VOLK, B
BERGER, M
机构
[1] HEINRICH HEINE UNIV, INST UMWELTHYG, DUSSELDORF, GERMANY
[2] UNIV FREIBURG, NEUROPATHOL ABT, W-7800 FREIBURG, GERMANY
关键词
INTERLEUKIN-6; NEURON; ACUTE PHASE RESPONSE; METALLOTHIONEIN; CILIARY NEUTROPHIC FACTOR; LEUKEMIA INHIBITORY FACTOR; INTERLEUKIN-1; ALZHEIMERS DISEASE; ALUMINUM;
D O I
10.1016/0165-5728(93)90177-Z
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Since immunohistochemical studies indicated the presence of interleukin-6 in the cortices of patients with Alzheimer's disease, we were interested in the eventual biological effects of this cytokine on neuronal cells. We found that interleukin-6 and interleukin-1 induced metallothionein expression in a human neuronal (SH-SY5Y neuroblastoma) cell line. In contrast to metallothionein, amyloid precursor protein expression was unaffected by both cytokines. When searching in the same cell line for the expression of the classical 80-kDa interleukin-6 binding protein, which is part of the dimeric interleukin-6 receptor, we were unable to detect the respective mRNA. Our findings either indicate that the interleukin-6 receptor in these cells is expressed in extremely low levels or that interleukin-6 may act upon neuronal cells via a different, yet unknown neuronal receptor.
引用
收藏
页码:163 / 173
页数:11
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