FLUID-MECHANICAL DAMAGE OF ANIMAL-CELLS IN BIOREACTORS

被引：171
作者：
PAPOUTSAKIS, ET
机构：
[1] E. T. Papoutsakis is at the Department of Chemical Engineering, Northwestern University, Evanston, IL 60208-3120
来源：
TRENDS IN BIOTECHNOLOGY | 1991年 / 9卷 / 12期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/0167-7799(91)90145-8
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The fluid-mechanical and some biological aspects of damage to animal cells in bioreactors due to agitation and/or aeration are attracting renewed attention. In microcarrier bioreactors, cell damage is due to forces generated by the interaction of microcarrier beads with each other and also with small turbulent eddies. For freely suspended cells grown in mixed bioreactors, cell damage is most frequently due to bubble breakup or fast-draining liquid films around rearranging gas-liquid interfaces.
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页码：427 / 437
页数：11
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