ACQUIRED FACTOR-XI INHIBITOR IN CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：29

作者：

GOODRICK, MJ ^{[1
]}

PRENTICE, AG ^{[1
]}

COPPLESTONE, JA ^{[1
]}

PAMPHILON, DH ^{[1
]}

BOON, RJ ^{[1
]}

机构：

[1] DERRIFORD HOSP,DEPT HAEMATOL,PLYMOUTH,ENGLAND

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1992年 / 45卷 / 04期

关键词：

D O I：

10.1136/jcp.45.4.352

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A 71 year old man with chronic lymphocytic leukaemia (CLL) experienced excessive bleeding following transurethral resection of the prostate. Investigations showed a prolonged kaolin cephalin clotting time (KCCT) with low concentrations of factor XI. The prolonged KCCT was largely corrected by mixing with normal plasma but this correction was lost on incubation, confirming the presence of an inhibitor. He was treated with pulsed methylprednisolone and chlorambucil which resulted in the resolution of the bleeding problem and the loss of detectable circulating inhibitor.

引用

页码：352 / 353

页数：2

共 6 条

[1]

DELACADENA RA, 1988, BLOOD, V72, P1748

[2] SENSITIVE TEST DEMONSTRATING LUPUS ANTICOAGULANT AND ITS BEHAVIORAL PATTERNS [J].