INVIVO EFFECTS OF SINGLE OR COMBINED DIETARY ANTIMUTAGENS ON MUTAGEN-INDUCED CHROMOSOMAL-ABERRATIONS

被引：48
|
作者：
RENNER, HW
机构：
[1] Federal Research Centre for Nutrition
来源：
MUTATION RESEARCH | 1990年 / 244卷 / 02期
关键词：
Antimutagens; Chlorophyllin; In vivo chromosome aberration test; Thio-tepa; α-Linolenic acid methyl ester; β-Carotene;
D O I：
10.1016/0165-7992(90)90070-Z
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The food components chlorophyllin, β-carotene and α-linolenic acid (in its methyl ester form) were tested in Chinese hamsters for antimutagenic activity on the powerful mutagen thio-tepa. Each of these natural protective compounds inhibited by 70-85% the clastogenic effects induced by the mutagen. When 2 or 3 of these antimutagens were administered simultaneously no additive effects were observed. α-Linolenic acid methyl ester was the most effective antimutagen under the experimental conditons. © 1990.
引用
收藏
页码：185 / 188
页数：4
相关论文
共 50 条
  • [31] TIME COURSE OF FREQUENCIES OF SISTER CHROMATID EXCHANGE AND CHROMOSOMAL-ABERRATIONS INVIVO
    STUKALOV, SV
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1988, 106 (08) : 1168 - 1170
  • [32] CHROMOSOMAL-ABERRATIONS INDUCED BY ELF ELECTRIC-FIELDS
    DAMBROSIO, G
    SCAGLIONE, A
    DIBERARDINO, D
    LIOI, MB
    IANNUZZI, L
    MOSTACCIUOLO, E
    SCARFI, MR
    JOURNAL OF BIOELECTRICITY, 1985, 4 (01): : 279 - 284
  • [33] CHROMOSOMAL-ABERRATIONS IN MOUSE LYMPHOCYTES EXPOSED INVIVO AND INVITRO TO ALIPHATIC EPOXIDES
    DAS, L
    DAS, SK
    CHU, EHY
    SINSHEIMER, JE
    MUTATION RESEARCH, 1993, 299 (01): : 19 - 24
  • [34] CHROMOSOMAL-ABERRATIONS INDUCED BY PESTICIDES IN MEIOTIC CELLS OF BARLEY
    GROVER, IS
    TYAGI, PS
    CARYOLOGIA, 1980, 33 (02) : 251 - 259
  • [35] CYCLOPHOSPHAMIDE-INDUCED CHROMOSOMAL-ABERRATIONS IN NONTUMOROUS PATIENTS
    DOBOS, M
    SCHULER, D
    FEKETE, G
    HUMANGENETIK, 1974, 22 (03): : 221 - 227
  • [36] ON THE TYPES OF CHROMOSOMAL-ABERRATIONS INDUCED BY 8-METHOXYPSORALEN
    HOOK, GJ
    HEDDLE, JA
    MARSHALL, RR
    CYTOGENETICS AND CELL GENETICS, 1983, 35 (02): : 100 - 103
  • [37] CHROMOSOMAL-ABERRATIONS BY NEUTRON-INDUCED SLOW PARTICLES
    BERGMAN, R
    STURELID, S
    RADIATION RESEARCH, 1974, 59 (01) : 282 - 282
  • [38] CHROMOSOMAL-ABERRATIONS INDUCED BY LOW-ENERGY PROTONS
    TAKATSUJI, T
    SASAKI, MS
    JOURNAL OF RADIATION RESEARCH, 1983, 24 (01) : 70 - 70
  • [39] DRUG-INDUCED CHROMOSOMAL-ABERRATIONS IN BLOOMS SYNDROME
    HAYES, TG
    ANATOMICAL RECORD, 1978, 190 (02): : 610 - 610
  • [40] CHROMOSOMAL-ABERRATIONS OF LIVING CELLS INDUCED BY MICROWAVE RADIATION
    CHEN, KM
    SAMUEL, A
    HOOPINGARNER, R
    ENVIRONMENTAL LETTERS, 1974, 6 (01): : 37 - 46
12345