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- [32] MEDI 130-Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-thieno[2,3-d]pyrimidine: A novel classical antifolate with dual thymidylate synthase and dihydrofolate reductase inhibitory acitivity as potential antitumor agent ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236