EFFECTS OF DOPAMINE AUTORECEPTOR STIMULATION ON THE RELEASE OF COLOCALIZED TRANSMITTERS - INVIVO RELEASE OF DOPAMINE AND NEUROTENSIN FROM RAT PREFRONTAL CORTEX

被引：39
|
作者：
BEAN, AJ
DURING, MJ
ROTH, RH
机构：
[1] YALE UNIV,SCH MED,DEPT PHARMACOL,333 CEDAR ST,NEW HAVEN,CT 06510
[2] YALE UNIV,SCH MED,DEPT PSYCHIAT,NEW HAVEN,CT 06510
来源：
NEUROSCIENCE LETTERS | 1990年 / 108卷 / 1-2期
关键词：
Autoreceptor; Colocalization; Cotransmission; Dopamine; Microdialysis; Neurotensin; Prefrontal cortex;
D O I：
10.1016/0304-3940(90)90721-K
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The in vivo release of dopamine and neurotensin from the rat medial prefrontal cortex was studied using perfusion microdialysis coupled with sensitive radioimmunoassay and HPLC techniques. Following stimulation of dopamine autoreceptors with either apomorphine (30 μg/kg, s.c.) or EMD-23448 (10 μM in the perfusion buffer) a decrease in dopamine and an increase in neurotensin release was observed. The release of both substances was measured in the same dialysis sample. These data suggest that activation of dopamine autoreceptors in the prefrontal cortex produces opposing effects on the release of dopamine and neurotensin. © 1990.
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页码：143 / 148
页数：6
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