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Pediatric deep brain stimulation: a cautionary approach
被引:2
|作者:
Focquaert, Farah
[1
]
机构:
[1] Univ Ghent, Bioeth Inst Ghent, Dept Philosophy & Moral Sci, Ghent, Belgium
关键词:
D O I:
10.3389/fnint.2011.00009
中图分类号:
B84 [心理学];
C [社会科学总论];
Q98 [人类学];
学科分类号:
03 ;
0303 ;
030303 ;
04 ;
0402 ;
摘要:
Over the last three decades, large numbers of patients with otherwise treatment-resistant disorders have been helped by deep brain stimulation (DBS), yet a full scientific understanding of the underlying neural mechanisms is still missing. We have previously proposed that efficacious DBS works by restoring the balance of the brains resting state networks. Here, we extend this proposal by reviewing how detailed investigations of the highly coherent functional and structural brain networks in health and disease (such as Parkinsons) have the potential not only to increase our understanding of fundamental brain function but of how best to modulate the balance. In particular, some of the newly identified hubs and connectors within and between resting state networks could become important new targets for DBS, including potentially in neuropsychiatric disorders. At the same time, it is of essence to consider the ethical implications of this perspective. © 2011 Kringelbach, Green and Aziz.
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