PHARMACOKINETICS OF ISOSORBIDE-5-NITRATE DURING HEMODIALYSIS AND PERITONEAL-DIALYSIS

被引：7
|
作者：
EVERS, J [1 ]
BONN, R [1 ]
BOERTZ, A [1 ]
CAWELLO, W [1 ]
LUCKOW, V [1 ]
FEY, M [1 ]
ABOUDAN, F [1 ]
DICKMANS, HA [1 ]
机构：
[1] SCHWARZ LTD, MONHEIM, GERMANY
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1987年 / 32卷 / 05期
关键词：
D O I：
10.1007/BF00637678
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The pharmacokinetics of isosorbide-5-nitrate (IS-5-N) was studied in ten patients on haemodialysis (HD) after a single oral dose of 20 mg IS-5-N, and in six patients on continuous ambulatory peritoneal dialysis (CAPD) after repeated oral doses of 3 .times. 20 mg IS-5-N. There was significant removal of IS-5-N from blood during HD; Cmax decreased by about 20%, AUC(0-8 h) by 30% and t1/2 by about 20% from 4.3 to 3.4 h, and plasma clearance was increased by 81 ml/min. No important loss of IS-5-N was observed in patients on CAPD.
引用
收藏
页码：503 / 505
页数：3
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