Tyrosine Kinase Inhibitors in EGFR-Mutated Large-Cell Neuroendocrine Carcinoma of the Lung? A Case Report

被引：21

作者：

Aroldi, Francesca ^{[1
]}

Bertocchi, Paola ^{[1
]}

Meriggi, Fausto ^{[1
]}

Abeni, Chiara ^{[1
]}

Ogliosi, Chiara ^{[1
]}

Rota, Luigina ^{[1
]}

Zambelli, Claudia ^{[2
]}

Bna, Claudio ^{[3
]}

Zaniboni, Alberto ^{[1
]}

机构：

[1] Poliambulanza Fdn, Oncol Dept, Via Bissolati 57, IT-25124 Brescia, Italy

[2] Poliambulanza Fdn, Pathol Anat Dept, Brescia, Italy

[3] Poliambulanza Fdn, Radiol Dept, Brescia, Italy

来源：

CASE REPORTS IN ONCOLOGY | 2014年 / 7卷 / 02期

关键词：

Large-cell neuroendocrine carcinoma; Epidermal growth factor receptor mutation; Tyrosine kinase inhibitors; Gefitinib;

D O I：

10.1159/000365413

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Large-cell neuroendocrine carcinoma (LCNEC) of the lung is a high-grade carcinoma belonging to the neuroendocrine tumors of the lung and is different from typical lung large-cell carcinoma. It represents about 3% of all pulmonary malignancies and is characterized by neuroendocrine cytologic features. The treatment usually is platinum-based chemotherapy, however the outcome remains poor. Therefore new therapeutic options are needed. Tyrosine kinase inhibitors have demonstrated greater efficacy and better tolerability than standard chemotherapy in non-small-cell lung cancer harboring epidermal growth factor receptor (EGFR) mutations. EGFR gene mutations were also rarely identified in LCNEC. We report a patient with lung LCNEC activating EGFR mutations who showed an impressive response to gefitinib. (C) 2014 S. Karger AG, Basel

引用

页码：478 / 483

页数：6

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