UV-SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF SECNIDAZOLE IN BULK AND TABLET DOSAGE FORM

被引：2

作者：

Sonpetkar, Jinendra M. ^{[1
]}

Joshi, Deval V. ^{[1
]}

Patel, Nakul B. ^{[1
]}

Wagdarikar, Mansi J. ^{[1
]}

机构：

[1] Indira Coll Pharm, New Mumbai Pune Highway, Pune 411041, Maharashtra, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2012年 / 3卷 / 02期

关键词：

Secnidazole; Methanol: Double distilled water (30:70); UV-Visible Spectrophotometer;

D O I：

10.13040/IJPSR.0975-8232.3(2).536-38

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A simple, precise and accurate UV-Spectrophotometric method has been developed and validated for estimation of secnidazole in bulk and tablet dosage form. It shows maximum absorbance at 313 nm with methanol and water (30: 70). Estimation was carried out by A(1%1cm) and by comparison with standard. Calibration graph was found to be linear (r(2) =0.09998) over concentration range of 1-4 mu g/ml. The proposed methods appear to be simple, sensitive, and reproducible when checked for parameters like accuracy, precision, limit of detection for routine determination of secnidazole in bulk as well as in tablet. The methods can be adopted in its routine analysis.

引用

页码：536 / 538

页数：3

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