NEUROMEDIN-C BINDS CU(II) AND NI(II) VIA THE ATCUN MOTIF - IMPLICATIONS FOR THE CNS AND CANCER GROWTH

被引：43

作者：

HARFORD, C ^{[1
]}

SARKAR, B ^{[1
]}

机构：

[1] UNIV TORONTO, DEPT BIOCHEM, TORONTO, ON M5G 1X8, CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 209卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.1580

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuromedin C is a bombesin-like neuropeptide of the sequence Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2. Characterization of the amino terminal Cu(II), NL(II) binding motif in albumins led us to predict that any other peptides or proteins with the same motif would also bind Cu(II) and Ni(II) specifically (1). The primary sequence of neuromedin C contains the motif in the form Gly-Asn-His. Neuromedin C was therefore predicted to bind Cu(II) and Ni(II) specifically. The studies presented here confirm that prediction. These findings may have implications for the transport of Cu(II) within the central nervous system as well as both Menkes disease and Wilson disease. Both are genetic copper metabolism disorders which are characterized by severe neurological symptoms. In addition, Cu(II) may interfere with the neurotransmission or growth factor effects of neuromedin C. (C) 1995 Academic Press, Inc.

引用

页码：877 / 882

页数：6

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