REACTION OF 2,2-DIFLUOROVINYL KETONES WITH HETEROATOM NUCLEOPHILES - A GENERAL ONE-POT SYNTHESIS OF ALPHA-OXOKETENE ACETALS

被引：45

作者：

ICHIKAWA, J

KOBAYASHI, M

YOKOTA, N

NODA, Y

MINAMI, T

机构：

[1] Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu, 804, Sensui-cho, Tobata

来源：

TETRAHEDRON | 1994年 / 50卷 / 40期

关键词：

D O I：

10.1016/S0040-4020(01)85658-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,2-Difluorovinyl ketones readily react with heteroatom nucleophiles such as thiols, alcohols, and amines to undergo stepwise replacement of the two fluorine atoms via addition-elimination process. The reaction affords alpha-oxoketene acetals including S,S-, N,S-, N,N-, O,S-, and O,O-acetals in good to excellent yields.

引用

收藏

页码：11637 / 11646

页数：10

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